Mathematics of Complex Systems in Biology and Medicine
Mathématiques des systèmes complexes en biologie et en médecine
24 – 28 February 2020
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Scientific Committee
Comité scientifique Leonid Berlyand (Penn State University) Organizing Committee
Comité d’organisation Michel Cristofol (I2M, Aix-Marseille Université) For any further informations, contact |
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This conference aims to bring together researchers from different mathematical backgrounds and biologists or biophysicists studying complex systems arising in biology and medicine and to discuss new perspectives at the intersection between these different approaches.
Starting from a problem coming from biology, we are interested in the whole mathematical process leading to a better understanding of the biological issues through modeling. In particular: interpret the biological data, design a deterministic or probabilistic model, calibrate the model from the experimental data, study the mathematical properties of the model, obtain accurate approximations, and give a biological interpretation of the results. Statistical approaches, used to interpret large sets of experimental data can be then combined with the accurate deterministic or stochastic modeling of the phenomenon under consideration to arrive at a deeper level of understanding. These accurate models can be simplified into toy models that can be analyzed mathematically. In addition, a numerical treatment of the model can also help provide deeper understanding or further insight into the analysis of the original problem. This week conference will consider the following central questions
These questions are of real interest for the biology and medical communities. A portion of the speakers work directly in the biology or biophysics community and the other speakers are mathematicians that have a strong connection with biologists and medical doctors. During this week, discussion will be centered around mathematical fields that include topics such as systems of PDEs, integro-differential equations, systems of stochastic differential equations, inverse problems, and statistics. Applications to medicine, pharmacology and biophysics will be highlighted. |
Cette conférence a pour but à la fois de réunir des chercheurs de différents horizons (mathématiques, biologistes, biophysiciens) étudiant des systèmes complexes issus de la biologie et de la médecine, et de discuter de nouvelles perspectives à l’intersection de ces différentes approches.
Partant d’un problème issu de la biologie, nous nous intéressons à l’ensemble du processus mathématique conduisant à une meilleure compréhension des enjeux biologiques par la modélisation. En particulier : interpréter les données biologiques, concevoir un modèle déterministe ou probabiliste, calibrer le modèle à partir des données expérimentales, étudier les propriétés mathématiques du modèle, obtenir des approximations précises, et donner une interprétation biologique des résultats. Les approches statistiques, utilisées pour interpréter de vastes ensembles de données expérimentales, peuvent ensuite être combinées à la modélisation déterministe ou stochastique précise du phénomène à l’étude pour arriver à un niveau de compréhension plus profond. Ces modèles précis peuvent être simplifiés en modèles jouets qui peuvent être analysés mathématiquement. De plus, un traitement numérique du modèle peut aussi aider à mieux comprendre ou à approfondir l’analyse du problème initial. Durant cette semaine, la conférence se penchera sur les questions centrales suivantes
Ces questions sont d’un intérêt réel pour les milieux de la biologie et de la médecine. Une partie des conférenciers travaillent directement dans le milieu de la biologie ou de la biophysique et les autres conférenciers sont des mathématiciens qui ont un lien étroit avec les biologistes et les médecins. |
Larisa Beilina (University of Chalmers) Time-adaptive determination of drug efficacy in the mathematical model of HIV infection
Richard Bertram (Florida State University) Synergy Between Mathematical Modeling and Experimentation in the Study of Pulsatile Insulin Secretion
Céline Bonnet (CMAP / Ecole polytechnique) Modeling steady state and stress hematopoiesis from stem to red cells
Federica Bubba (Université Paris Sorbonne) PDE models for pattern formation in cultures of breast cancer cells
José Antonio Carrillo (Imperial College London) Attractive-repulsive models in collective behavior and applications
Martina Conte (Basque Center for Applied Mathematics) Mathematical modelling of glioma progression: the role of cellular protrusions
Fabien Crauste (CNRS, Université de Bordeaux) Mathematical modeling of CD8 T cell immune responses, from heterogeneous cell dynamics towards multiscale descriptions
Adriana De Mendoza (TU Dresden) The Jung model as a unified kinetic model for the prediction of the combined hyperthermia and radiation treatment outcomes
Raluca Eftimie (University of Dundee) Understanding the role of macrophages’ plasticity and heterogeneity in the evolution of tumours: mathematical approaches
Ján Eliaš (University of Graz) Mathematical modelling of lipolysis
Giada Fiandaca (Polytechnic University of Turin) A mathematical model for the emergence of intratumour metabolic heterogeneity
Thierry Goudon (INRIA Nice) A PDE model describing the immune cells-tumor growth interactions
Céline Grandmont (INRIA Paris) Mathematical modelling of the ventilation. Application to the study of Heliox Effectiveness and to the idenfication of bronchoconstrictions
Ulysse Herbach (Institut Élie Cartan de Lorraine) Inferring gene networks with single-cell data: from mechanistic modelling to statistics
Thomas Hillen (University of Alberta) Non-local Models for Cellular Adhesion
Trachette Jackson (University of Michigan) Mathematical Modeling of Targeted Cancer Therapeutics
Natalia Komarova (University of California, Irvine) Mathematical modeling of cell population evolution
Anita Layton (University of Waterloo) The Kidney, diabetes, and hypertension: Modeling and analysis
Alexandra Lefebvre (CNRS / Sorbonne université) A Mendelian model based on probabilistic graphical models and multi-state models to compute risks in genetic diseases. Application to the Lynch syndrome
Paul Lemarre (Université Claude Bernard Lyon 1) Using impulsive differential equations to model the propagation of yeast prions
Bertrand Maury (Université Paris Sud) Morphometry / visualization of the deep lung
Nadia Loy (Polytechnic University of Turin) Modelling physical limits of migration by a kinetic model with non-local sensing
Nicolas Meunier (Université d’Évry Val d’Essonne) Motility and Morphodynamics of Confined Cells
Vuk Misilic (Université Paris 13) Modeling and mathematical analysis of adhesion forces in the context of cell motility: a gradient flow approach
Chaouqi Misbah (Université Grenoble Alpes) Modeling Swimming of Leukocytes
Philippe Moireau (INRIA Saclay) Multiscale models of the cardiac contraction
Peter Rashkov (Bulgarian Academy of Sciences) Challenges and complexity in modelling the host’s immune response to mature and immature dengue viruses
Vincent Rivoirard (Université Paris-Dauphine) Nonparametric estimation for size-structured populations of cells
Shawn Ryan (Cleveland State University) Mathematics Provides Insight Into Self-Organization in Active Biosystems
Christian Schmeiser (University of Vienna) Kinetic modeling for myxobacteria alignment and reversal interactions
Angela Stevens (WWU Münster) Signaling gradients in surface dynamics as basis for planarian regeneration
Cécile Sykes (Institut Curie, Paris) Cell-like membranes are shaped by actin dynamics
Min Tang (Shanghai Jiao Tong University) Fractional diffusion of E. coli chemotaxis due to internal noise
Rémi Tesson (ENS Paris-Saclay) Estimating relapse risks for glioblastomas with Level-set and Machine Learning methods
Annie Viallat (CI
NAM, Marseille) Biological fluids: mucus swirling, white blood cells snaking, and red blood cells swinging
Romain Yvinec (INRA) Modeling (some aspects of) the female reproductive system
1. Safaa Al Ali , Sébastien Li-Thiao-Té, John Chaussard and Hatem Zaag,(Université Paris 13)
Mathematical modeling of the spatial distribution of lesions in inammatory bowel disease
2. O. Angelin-Bonnet , Susan Thomson, Samantha Baldwin, Patrick J. Biggs, Matthieu Vignes (Massey University)
Stochastic simulations of gene regulatory networks with sismonr
3. Kevin Atsou (Université de Nice)
A size and space structured model describing interactions between tumor cells and cytotoxic effector immune cells: Analysis of the equilibrium phase in immune-controlled tumor
4. Valeria Caliaro (INRIA Paris)
Mathematical modeling of regenerative processes in axolotl spinal cord
5. Noemie David , B. Perthame (Sorbonne Université, Paris)
Hele-Shaw limit for a tumor growth model with nutrients
6. Nicolas Garcia Seyda , Aoun Laurene, Seveau Valentine, Bajenoff Marc, Theodoly Olivier (LAI, Marseille)
Microfluidic tools to image chemotaxis of swimming leukocytes
7. Simon Girel , Jacqueline Marvel, Christophe Arpin, Olivier Gandrillon, Fabien Crauste (Institut de Mathématique de Bordeaux)
Regulation of cellular heterogeneity by uneven molecular partitioning during the CD8 T-cell immune response
8. Emma Leschierra , Tommazzo Lorenzi, Luis Almeida, Chloé Audebert (Sorbonne Université, Paris)
Discrete and continuum models of the co-evolution between antigen-specic T cells and target cells
9. Fabio Manca (LAI, Marseille)
Two-state theory of single-molecule stretching experiments : applications to SNARE proteins and T cell receptors
10. Saulo de Matos Da Silva , Florence Hubert, Magali Tournus (Marseille)
Asymptotics of a Simple Model of Microtubule Dynamical Instabilities
11. Alejandro Nieto Ramos , Elizabeth Cherry (Rochester Institute of Technology)
Bayesian Inference in Cardiac Models
12. Daryl Ondoua , Yvon Maday, Benoit Sarels (Sorbonne Université, Paris)
Modeling symbiosis between two species living in a host
13. Pierre Pudlo , Sophie Chauvet, Jéremy Guillot, Florence Hubert, Fanny Mann (Aix-Marseille Université)
Role of the sympathetic nervous system in pancreatic cancer
14. Anais Rat (Ecole centrale Marseille)
Effect of variability in growth rate on the Malthus parameter of a size-structured cell population
15. Michèle Romanos (Université Toulouse III)
Mathematical modeling of embryo axis elongation
16. Mehrshad Sadria (University of Waterloo)
Network centrality analysis of eyegaze data in autism spectrum disorder
17. Daniel Schindler ,Ted Moldenhawer, Carsten Beta, Matthias Holschneider, Wilhelm Huisinga (Postdam)
Spatiotemporal tracking of virtual markers on moving cell outlines
18. Valentine Seveau de Ronay , Xuan Luo, Martine Biarnes, Marie-Pierre Valignat, Olivier Theodoly, Vincent Studer, Pierre-Olivier Strale (LAI, Marseille, FRANCE) T Cell adhesive haptotaxis
19. Nina Verstraete , Hélène Arduin, Marcin Domagala, Mary Poupot, Vera Pancaldi (Université de Toulouse)
Modelling the differentiation dynamics of monocytes in contact with B-CLL cancer cells
The best 4 posters will get prizes. Prizes to be won:
Transport equations in biology, Benoit Perthame
Parabolic equations in biology, Benoit Perthame
Mathematical Physiology, James Keener
The dynamics of physiologically structured population, J Metz and O Diekmann
