May 28-29, 2015
The modelling and the analysis of biomolecular networks constitutes a growing scientific field, and the models considered are of increasing size and complexity. Hence, more and more attention is paid on, and efforts related to reduction methods. The choice of the reduction method may depend on the biological process modeled, the mathematical formalism used, the available data etc.
One of the main criteria for this choice relies on the ability of the reduction to keep the fundamental dynamical properties of the original model. Indeed, without specific controls, transient and asymptotic behaviours, circuit functionalities, time scales, etc. can be impacted by the reduction, which can harm the biological interpretations.